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A group of girls are in line at a concert, two of the teenage girls try to crash backstage and succeed. Jordan and Phoebe get invited to a party after the concert. The next day they sit at a restaurant telling their friends all about their evening when Jordan’s feet and hands swell and she collapses.

Wilson gets ready for a weekend pharmacology conference. Part of House’s rehab is staying with Wilson and Wilson expects House to go to the conference with him. House says no to the conference until he finds out Cuddy is going. Wilson sits with one of his patients who is suffering through the end stage of cancer.

Jordan is being examined by Foreman and Chase. House says Jordon has Rhabdo after putting her through a drumming test and evaluating her arm strength. House tells Foreman and Chase Jordan is lying about what happened the night before, states her potassium levels are low and orders tests for Rhabdo. During the lab tests Chase admits to Foreman his marriage may be in trouble.

Jordan continues to stick by her story. Phoebe and Jordon finally admit they went to the concert because they are major fans of Keener, the creator of a comic book series who attended the concert and party. The girls followed Keener around the hotel spying on his activities. Foreman wonders if food is the problem. Cameron takes samples of the food the girls ate at the concert party. Cameron thinks bulimia might explain Jordan’s symptoms.

Wilson and House pick up Cuddy and her child on the way to the conference. Wilson is scheduled to give a talk at the conference and House wonders why Wilson did not ask for his advice by reading his paper as he has always done before. Jordan’s parents arrive at the hospital, it is clear her wealthy parents are usually off on business and rarely home with her. Jordan continues to lie about what happened at the hotel. Shortly after her parent’s arrival Jordan goes into cardiac arrest. The team calls House who believes Jordan’s condition is acute and not chronic, limiting her illness to toxins and infection.

Cameron meets with Keener at the hotel and asks what went on with the girls. Keener tells Cameron they followed him around the hotel but that was the extent of his contact with them. Jordan is bleeding into her brain affecting her thalamus. Foreman tells Phoebe because of the bleeding into her brain, whatever Jordan says to her or anyone else is a lie. Phoebe admits that Jordon left their hotel room during the night and she is not sure where she went.

The conference is holding an 80’s themed party. The doctors are dressed in costume; Cuddy dresses in a Flashdance 80’s style. House appears dressed in an 1780s costume complete with powdered wig. House and Cuddy slow dance to an 80’s tune. House admits to Cuddy even back in medical school he was interested in her. Cuddy leaves the party abruptly. Wilson asks Cuddy about the party the next day and Cuddy tells him she needs someone more stable than House in her life because she is a mother now.

Wilson gets a call telling him his cancer patient died. Wilson tells House about his conversation with Cuddy and suggests House offer to be more reliable by babysitting for Cuddy while she attends sessions. After House finds out Wilson’s paper is on euthanasia, he insists Wilson’s talk would be professional suicide and tells Wilson he must cancel his talk.

The team views the hotel security video, showing Jordan getting on the elevator with Keener. Cameron and Foreman confront Keener who continues to insist he had no contact with Jordan. Jordan begins bleeding from her kidneys and Cameron suspects Keener gave her drugs and seduced her. Cameron suggests using a truth serum on Jordan. Chase and Cameron clash over the treatment of Jordan and their personal problems.

House pours Wilson a laced fruit drink to keep him from making his talk at the conference. House goes to Cuddy’s hotel room to offer his babysitting services. As Cuddy makes an excuse House hears the baby cry and sees Lucas, the private detective House hired previously, holding the baby. House realizes Cuddy is dating Lucas and leaves.

Jordon tells the doctors and her parents Keener drugged and seduced her. From House’s advice on the case Foreman can tell Jordan is lying. The brain bleed gets worse as blood trickles from Jordan’s ear and Jordan is dying. The team tests Jordan for Rickettsia, a disease she may have caught from Keener’s dog.

House gives Wilson’s talk in his place since he’s already impersonating another doctor to gain entry to the conference. Wilson arrives groggy from the drugs and confronts House, who tells Wilson he should not feel guilty since did everything possible for his cancer patient. Wilson appreciates House’s support but not his methods.

House calls the team, telling them Jordan’s blood is what is killing her. Jordan has Hemochromatosis, eating fresh oysters at the restaurant caused Vibrio vulnificus, and the iron supplements she took for bulimia caused her internal bleeding. The team successfully treats Jordan with ceftazidime for the Vibrio and chelated for the Hemochromatosis. As Jordan begins to feel better she confesses to Cameron she wasn’t brave enough to knock on Keener’s door, leaving the journal at the door instead. Cameron realizes she was wrong about Keener.

House and Wilson sit awkwardly with Cuddy, Lucas and the baby at a restaurant to learn about their relationship. At home, Cameron asks Chase what is going on with him. Chase tells her he is not having an affair. Chase finally gets the courage to tell Cameron about his role in Dibala’s death.