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A porn movie is being filmed and the lead actor Hank Hardwick suddenly starts screaming in pain from the movie lights and 911 is called. Cameron and Chase talk about Dibala. Cameron tells Chase she doesn’t agree with what he did ethically but will stand by him. Cameron suggests she and Chase leave their jobs at the hospital. Cuddy presents House with his reinstated medical license, meaning House is back in charge. Just then Cameron and Chase walk in to tell Foreman and House they are resigning. House decides to contact Thirteen and Taub hoping to convince them to rejoin the team.

As the team questions Hank and his wife, who also works in the porn industry, they find they lead a very clean lifestyle other than their profession. Hank’s muscles contract, causing pain. Foreman tells House he thinks its Cerebral vasculitis and House has him run tests.

House appears at Taub’s plastic surgery office and tries to get him involved in Hank’s case. Taub declines the job offer but suggests there may be a problem with Hank’s brain. House visits Thirteen at her home, drawing her into the case and hinting at coming back to the team. Thirteen declines as well and suggests Hank’s symptoms point to a multifocal diagnosis.

Foreman needs Cameron and Chase to help on the case. As they clean out their lockers he convinces them to help him since he is the only one left on the team to run tests. Hank is tested with UV light and as he is in the booth his nose starts bleeding profusely and his legs are covered in a rash. As the team reports their findings to House Cameron gets angry with House. House asks Cameron why she reacted to his suggestion to use antibiotics. House tells Cameron she is mad at him but Chase is responsible for what happened to Dibala. Chase and Hank talk about relationships. Chase gives Hank the antibiotics but Hank develops a fever in spite of the medicine he receives.

House shows up at Taub’s office pretending to be various patients on his daily roster. Taub tells House if Hank’s sinuses are clogged the antibiotics would not work. Chase drains Hank’s sinuses while House analyzes why Cameron is reacting the way she is. House tells Chase that Cameron is angry about House and his part in involving them in Dibala’s care and that it will not be possible for her to forgive killing a patient due to her medical ethics.

Foreman takes a turn at convincing Thirteen to rejoin the team. Wilson talks with Cuddy about her relationship with House. Cuddy talks with Lucas about House and they connect while solving any issues related to him.

As they work on Hank, Chase asks Cameron why she was able to forgive him and she tells him because he is sorry for what he did. Chase tells Cameron even though he is sorry for what he did he would do the same thing again given the opportunity to saves thousands of lives. Cameron is startled at Chase’s admission. Hank’s stomach bloats, showing signs of liver failure. Chase thinks that the inflammation could involve Hank’s bile ducts.

House hounds Thirteen at her gym about rejoining the team. Cameron tells Hank and his wife that his liver is failing and he will need a liver transplant. She tells Hank he must give up his profession because the health risks of his job will keep him from being approved for a new liver. Chase performs a ERCP test that shows worms are filling Hank’s liver, and gives Hank mebendazole pills.

After Hank coughs up fluid from his lungs Foreman concludes he has lymphoma. House sends faxes to Cameron and Taub to keep them in the loop and Cameron is upset about his remarks. As they leave Chase asks Cameron if she is angry with House. Chase discovers Cameron is angry about House and his part in involving them in Dibala’s care and Chase’s actions leading to Dibala’s death. Chase tells Cameron he is the one who is responsible not House.

When Hank begins chemo he starts to bleed in his urine and goes into cardiac arrest. House chooses bone marrow as the next step in tests but the team believes the test could kill Hank. House faxes an update to Taub and Thirteen. As Hank is prepared for his bone marrow procedure, Taub and Thirteen call in conference to talk to House and the team. They explain that Hank’s immune system began to attack him because he lived such a clean lifestyle, the worms he had kept his Chrohn’s disease at bay. Hank will be treated with a new set of worms and will recover.

Chase admits to Cameron that he wants to stay on House’s team. Cameron feels them pull apart. Cameron confronts House, and is angry that he almost let Hank die in order to get the team members back. Cameron tells House she loved him and that she still loves Chase. Cameron tells House he is ruined and now he has ruined Chase and there is no turning back for either of them. House watches Cameron leave the hospital.

House tells Wilson he succeeded in winning back the three the team members but lost Cameron. Thirteen delivers the prescription of worms to Hank as Foreman watches. Taub explains to his unhappy wife he is going back to work for the team. Cameron hugs Chase and leaves the apartment with suitcases packed. House seems sullen as he watches Cuddy and Lucas leave the hospital together.