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Courier Jimmy Sidas arrives at a scientific bookstore for a delivery. The bookstore owner recognizes him as a famous scientist and asks for an autograph. Jimmy finally agrees then realizes he is unable to write his name.

Cuddy runs into House at work and gives him the Sidas case. House is acting very nice, which makes Cuddy suspicious. House hints at Thanksgiving, asking her what her plans are. Taub, Thirteen, Foreman and Chase meet with House to discuss the Sidas case. They note that Jimmy changed his career from a known scientist to courier, an odd choice for a genius. They suspect a diagnosis of TTP. House orders blood tests taken.

Foreman and Chase discuss the case. Foreman asks Chase about Cameron and Chase evades the conversation saying he is fine. The team meets with Jimmy who states he chose to be a courier because he can spend more time with his wife and kid, life is happier that way. Taub and Thirteen are given the task of tests and find TTP as they suspected.

Jimmy has an allergy so the doctors cannot treat him with plasmapherresis for TTP. House and the team agree that because of the allergy, the next step is to remove Jimmy’s spleen. House visits Wilson and tells him he is working on getting an invitation to Cuddy’s sister’s house for Thanksgiving. House plans to break up Cuddy and Lucas. Wilson warns him against drama at the Thanksgiving dinner and chooses not to help in the plot.

After the splenectomy, Chase meets with Jimmy and his wife to discuss when Jimmy can leave the hospital. Jimmy begins talking nonsense and mentioning colors. Chase realizes Jimmy is having a stroke and calls for help. The team meets with House to discuss Jimmy’s condition. Chase tells them Jimmy has no long term effects from the stroke. House asks the team what acts like TTP. House sends Taub and Chase to Jimmy’s house to investigate if possible toxins are present. They find a hidden Vodka bottle, pointing to alcohol problems. Taub invites Chase to Thanksgiving dinner and Chase declines, becoming irritated so many of the team are questioning him about Cameron. They find elaborate scientific notes on atoms and are surprised again how Jimmy can throw away his career.

House parries with Cuddy again, hinting for an invitation. Cuddy finally invites House to Thanksgiving dinner. House tells Wilson he got his invitation and his plan to break up Cuddy and Lucas is working. The team decides Jimmy’s symptoms point to liver failure. Taub and Thirteen are stuck on Thanksgiving day running tests to check Jimmy’s liver. House arrives at Cuddy’s sister’s house only to find that Cuddy, Lucas and her family are out of town. House is stunned and upset that Cuddy would dupe him.

Lucas arrives at home to find House has used his extra key to get into his apartment. House appears drunk and rambles about Cuddy. House tries to stand up and starts to fall, with Lucas catching him. House reveals to Lucas he is in love with Cuddy. House calls in sick for the day. The team thinks Jimmy may be in kidney failure and set him up for dialysis. Thirteen asks Chase about Cameron and Chase evades her questions. Cuddy visits House at home and asks him what he said to Lucas. Cuddy tells House she and Lucas broke up because of his conversation with Lucas and she will never have a relationship with House. When Wilson arrives home House is giddy telling him Lucas fell for his sob story and he succeeded in breaking up Cuddy and Lucas.

Jimmy completes his kidney dialysis and is feeling better. Jimmy coughs and mentions needing cough syrup. As Jimmy draws a scientific diagram his wife is impressed. House confronts Jimmy and tells him he is “Robo tripping” to dumb himself down, a term used for abuse of cough syrup, with a shot of alcohol to keep a lower level of brain damage from occurring. Jimmy admits his addiction to his wife and House. Suddenly Jimmy cannot feel anything in his legs and panics.

Taub and his wife have a conversation about his job with the team. Taub’s wife calls him a wimp for going back to grub work instead of running his own office. House talks to the team, getting suggestions for a diagnosis. House goads Chase saying he is not working as hard as the rest of the team. Chase stands up, walks over to House and punches House in the face, knocking him to the floor. As House staggers back to his feet Chase leaves. Taub asks House if he can take a phone photo of him beat up and House says why not.

Jimmy confides to House that life is easier if he is stoned. Jimmy tells House his IQ is 91 points above his wife’s IQ. If he isn’t stoned he finds it impossible to want to stay with her. Jimmy tells House his own genius moved him to suicide, jumping off a building twelve years ago and breaking three ribs. House realizes the ribs may never have healed and orders an MRI. The MRI reveals rib pieces that have split his spleen into sixteen pieces. Removing the spleen pieces will resolve his medical condition. Jimmy tells House his genius is a curse to him, recognizing House is a genius and can relate. House finds Jimmy some cough syrup to help him cope.

Chase finds House and apologizes for his injuries. House tells Chase he probably deserved it. They have a meeting of the minds with no charges against Chase. Cuddy visits House at home and asks about charges for the Chase incident. House tells Cuddy there are no charges, he fell over an ottoman and Chase helped him. Cuddy is dubious about House and Chase’s actions. House finds Cuddy at the hospital and offers tickets for her and her daughter to go to a petting zoo. Cuddy says no thanks. House knows Cuddy didn’t break up with Lucas. Cuddy meets Lucas at home and tells him House knows they didn’t break up.

Taub arrives at home and shows his wife the camera photo of House. Taub’s wife asks if Taub hit House and he says yes, he made him angry so he punched him out. Taub’s wife is suddenly impressed with Taub standing up to House.